SNPeffect

PTN14_HUMAN

Compact overview of PTN14_HUMAN
UniProt Entry NamePTN14_HUMAN
Protein NameTyrosine-protein phosphatase non-receptor type 14
Protein FunctionN.A
Length1187 residues
Gene ontology overview of PTN14_HUMAN
Cellular componentMolecular functionBiological process
cytoplasm
cytoskeleton
binding
protein tyrosine phosphatase activity
protein dephosphorylation
Phenotypic summary of PTN14_HUMAN
Short stretch summary of PTN14_HUMAN
PredictorPredicted regions overviewStretchesTotal score
Tango 84004
Waltz 143576
Limbo 1510685
Domain composition of PTN14_HUMAN
DatabaseDomain compositionResidue details
SMARTB41 (Residues 17-220), PTPc (Residues 908-1182)
PFAMFERM_N (Residues 25-103), FERM_M (Residues 104-220), FERM_C (Residues 224-309), Y_phosphatase (Residues 933-1179)
TANGO aggregation profile of PTN14_HUMAN
TANGO regions in PTN14_HUMAN
N-term gatekeepersTANGO regionC-term gatekeepersStartEndScore
LRETHYFGLWFLSKSQQA616869
FANEPLLFFGVMFYVPNVSW9410384
DNHGNCVHLGIFFMGIFVRNRIG22924169
ITHNKSTILVELINK2652698
VWEQGVNVIAMVTAEEEG1002100948
NRHPPIVVHCSAGVG111711215
AGVGRTGVLILSELMIY1128113442
IAQYKFVYQVLIQFLQNSRL1172118182
TANGO aggregation profile score plot


This graph plots the per-residue TANGO aggregation score of the protein PTN14_HUMAN. From left to right, all residue scores from the N-terminus to the C-terminus are plotted


Molecular visualization of TANGO aggregation-prone regions

Wild type PTN14_HUMAN

This molecular image shows the TANGO aggregation-prone regions as red colored segments. Click on the image to get a larger view and to download the original.


WALTZ amylogenic profile of PTN14_HUMAN
WALTZ regions in PTN14_HUMAN
N-term gatekeepersWALTZ regionC-term gatekeepersStartEndScore
QQEATRYQYYLQVKKD11512060
QDFLREYVLFPMDLAL1641695
LPAEAELMYINEVERL2022076
NRIGRQAVIYRWNDMG24825356
NKSTILVELINKEETA26827362
NSHNSLDLNYLNGTVT37437963
NSLNCSQSFIQASPVS40040513
SQSLRNLNIINTHAYN46847395
PTKENNTGYINASHIK95996411
VVVGGAEWHYIATQGP97598046
PEDVQGFLSYLEEIQS1088109316
AGVGRTGVLILSELMI1128113329
EQRMFMIQTIAQYKFV1163116828
QYKFVYQVLIQFLQNS1174117982
WALTZ aggregation profile score plot


This graph plots the per-residue WALTZ amylogenic score of the protein PTN14_HUMAN. From left to right, all residue scores from the N-terminus to the C-terminus are plotted


Molecular visualization of WALTZ amylogenic regions

Wild type PTN14_HUMAN

This molecular image shows the WALTZ amylogenic regions as blue colored segments. Click on the image to get a larger view and to download the original.


LIMBO chaperone binding profile of PTN14_HUMAN
LIMBO regions in PTN14_HUMAN
N-term gatekeepersLIMBO regionC-term gatekeepersStartEndScore
MPFGLKLRRTRRYNVLSK61371.4
QQARWVELEKPLKKHLDK768399.4
DFLREYVLFPMDLALEEA16517290.4
VHLGIFFMGIFVRNRIGR23524299.9
RLFATRHKFYKQNKICTEQSN29830839.9
RPTPDYETVMRQMKRGIL44545295.4
AHMLKNYLFRPPPPYPRP56156899.9
MTLKSLHLPMARRNTLRE66166899.9
AMARARVLRHGPAKAISM77978699.9
DSIIEREMMIRNLEKQKM843850100
VPMDERFRTLKKKLEEGMV89690477.4
GGAEWHYIATQGPLPHTC978985100
ERTVWHLQYTDWPDHGCP1071107890.3
PEDVQGFLSYLEEIQSVR108810956.7
KFVYQVLIQFLQNSRLI1176118398.3
LIMBO chaperone binding profile score plot


This graph plots the per-residue LIMBO chaperone binding score of the protein PTN14_HUMAN. From left to right, all residue scores from the N-terminus to the C-terminus are plotted


Molecular visualization of LIMBO chaperone binding regions

Wild type PTN14_HUMAN

This molecular image shows the LIMBO chaperone binding regions as pink colored segments. Click on the image to get a larger view and to download the original.


All mutations from PTN14_HUMAN

3 mutations listed

Variant UniProt ID Mutation Disease Mutation Type dTANGO dWALTZ dLIMBO ddG
VAR_046995 PTN14_HUMAN V505F - Polymorphism 0 0 0 N.A.
VAR_035850 PTN14_HUMAN H360P A breast cancer sample Unclassified 0 1 0 N.A.
VAR_035849 PTN14_HUMAN Q159E A breast cancer sample Unclassified -1 -1 0 N.A.
Comma Separated Values documentMicrosoft Excel document