| Compact overview of 1A01_HUMAN | ||
|---|---|---|
| UniProt Entry Name | 1A01_HUMAN | |
| Protein Name | HLA class I histocompatibility antigen, A-1 alpha chain | |
| Protein Function | Involved in the presentation of foreign antigens to the immune system. | |
| Length | 365 residues | Gene ontology overview of 1A01_HUMAN |
| Cellular component | Molecular function | Biological process | integral to plasma membrane MHC class I protein complex | MHC class I receptor activity | antigen processing and presentation of peptide antigen via MHC class I interferon-gamma-mediated signaling pathway interspecies interaction between organisms regulation of immune response type I interferon-mediated signaling pathway |
Phenotypic summary of 1A01_HUMAN
| Short stretch summary of 1A01_HUMAN | |||
|---|---|---|---|
| Predictor | Predicted regions overview | Stretches | Total score |
| Tango |  | 6 | 2880 |
| Waltz |  | 0 | 21 |
| Limbo |  | 5 | 3190 |
| Domain composition of 1A01_HUMAN | |||
| Database | Domain composition | Residue details | |
| PFAM |  | MHC_I (Residues 25-203), C1-set (Residues 211-295), MHC_I_C (Residues 336-364) | |
| SMART |  | IGc1 (Residues 222-293) | |
TANGO aggregation profile of 1A01_HUMAN
| TANGO regions in 1A01_HUMAN | |||||
|---|---|---|---|---|---|
| N-term gatekeepers | TANGO region | C-term gatekeepers | Start | End | Score |
| VMAPR | TLLLLLSGALALT | QTWAG | 8 | 20 | 44 |
| HSMRY | FFTSV | SRPGR | 32 | 36 | 6 |
| RGEPR | FIAVGYV | DDTQF | 46 | 52 | 77 |
| FYPAE | ITLTW | QRDGE | 237 | 241 | 13 |
| GTFQK | WAAVV | VPSGE | 268 | 272 | 11 |
| QPTIP | IVGIIAGLVLLGAVITGAVVAAVMW | RRKSS | 308 | 332 | 63 |
| TANGO aggregation profile score plot | |
|---|---|
 | This graph plots the per-residue TANGO aggregation score of the protein 1A01_HUMAN. From left to right, all residue scores from the N-terminus to the C-terminus are plotted |
| Molecular visualization of TANGO aggregation-prone regions | |
|---|---|
 Wild type 1A01_HUMAN | |
This molecular image shows the TANGO aggregation-prone regions as red colored segments. Click on the image to get a larger view and to download the original. | |
WALTZ amylogenic profile of 1A01_HUMAN
| WALTZ regions in 1A01_HUMAN | |||||
|---|---|---|---|---|---|
| N-term gatekeepers | WALTZ region | C-term gatekeepers | Start | End | Score |
| WALTZ aggregation profile score plot | |
|---|---|
 | This graph plots the per-residue WALTZ amylogenic score of the protein 1A01_HUMAN. From left to right, all residue scores from the N-terminus to the C-terminus are plotted |
| Molecular visualization of WALTZ amylogenic regions | |
|---|---|
 Wild type 1A01_HUMAN | |
This molecular image shows the WALTZ amylogenic regions as blue colored segments. Click on the image to get a larger view and to download the original. | |
LIMBO chaperone binding profile of 1A01_HUMAN
| LIMBO regions in 1A01_HUMAN | |||||
|---|---|---|---|---|---|
| N-term gatekeepers | LIMBO region | C-term gatekeepers | Start | End | Score |
| MAPRT | LLLLLSGA | LALTQ | 9 | 16 | 100 |
| DGSHT | IQIMYGCD | VGPDG | 119 | 126 | 11.1 |
| IALNE | DLRSWTAA | DMAAQ | 153 | 160 | 85 |
| FYPAE | ITLTWQRD | GEDQT | 237 | 244 | 100 |
| GLPKP | LTLRWELS | SQPTI | 294 | 301 | 97 |
| LIMBO chaperone binding profile score plot | |
|---|---|
 | This graph plots the per-residue LIMBO chaperone binding score of the protein 1A01_HUMAN. From left to right, all residue scores from the N-terminus to the C-terminus are plotted |
| Molecular visualization of LIMBO chaperone binding regions | |
|---|---|
 Wild type 1A01_HUMAN | |
This molecular image shows the LIMBO chaperone binding regions as pink colored segments. Click on the image to get a larger view and to download the original. | |
All mutations from 1A01_HUMAN
16 mutations listed
| Variant | UniProt ID | Mutation | Disease | Mutation Type | dTANGO | dWALTZ | dLIMBO | ddG |
|---|---|---|---|---|---|---|---|---|
| VAR_056253 | 1A01_HUMAN | R205H | - | Polymorphism | -1 | 0 | 0 | 1.35 |
| VAR_056250 | 1A01_HUMAN | N151K | - | Polymorphism | 0 | 0 | 0 | 0.24 |
| VAR_056251 | 1A01_HUMAN | I166T | - | Polymorphism | 0 | 0 | 0 | 0.96 |
| VAR_056252 | 1A01_HUMAN | R169H | - | Polymorphism | -1 | 0 | 0 | 0.31 |
| VAR_016725 | 1A01_HUMAN | V182A | - | Polymorphism | 0 | 0 | 0 | -0.31 |
| VAR_056247 | 1A01_HUMAN | R89G | - | Polymorphism | -1 | 0 | 0 | 1.57 |
| VAR_056248 | 1A01_HUMAN | G131W | - | Polymorphism | 0 | 0 | 9 | 3.3 |
| VAR_056249 | 1A01_HUMAN | F133L | - | Polymorphism | 0 | 0 | 0 | 1.23 |
| VAR_016723 | 1A01_HUMAN | I121M | - | Polymorphism | -11 | -1 | 3 | 0.79 |
| VAR_016724 | 1A01_HUMAN | R180L | - | Polymorphism | 0 | 0 | 1 | -1.91 |
| VAR_016721 | 1A01_HUMAN | A100E | - | Polymorphism | 0 | 0 | 0 | -0.04 |
| VAR_004333 | 1A01_HUMAN | R41S | - | Polymorphism | -1 | 0 | 0 | 1.04 |
| VAR_016720 | 1A01_HUMAN | M91V | - | Polymorphism | 0 | 0 | 0 | 4.3 |
| VAR_016719 | 1A01_HUMAN | G80R | - | Polymorphism | 1 | 0 | 0 | 0.47 |
| VAR_004332 | 1A01_HUMAN | F33S | - | Polymorphism | -34 | -6 | 0 | 6.14 |
| VAR_016722 | 1A01_HUMAN | D114A | - | Polymorphism | 0 | 0 | 0 | 0.42 |
