1A33_HUMAN

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Compact overview of 1A33_HUMAN
UniProt Entry Name1A33_HUMAN
Protein NameHLA class I histocompatibility antigen, A-33 alpha chain
Protein FunctionInvolved in the presentation of foreign antigens to the immune system.
Length365 residues
Gene ontology overview of 1A33_HUMAN
Cellular componentMolecular functionBiological process
integral to membrane
MHC class I protein complex
antigen processing and presentation of peptide antigen via MHC class I
immune response
interspecies interaction between organisms

Phenotypic summary of 1A33_HUMAN

Short stretch summary of 1A33_HUMAN
PredictorPredicted regions overviewStretchesTotal score
Tango 43186
Waltz 149
Limbo 53199
Domain composition of 1A33_HUMAN
DatabaseDomain compositionResidue details
PFAMMHC_I (Residues 25-203), C1-set (Residues 209-295), MHC_I_C (Residues 336-364)
SMARTIGc1 (Residues 222-293)

TANGO aggregation profile of 1A33_HUMAN

TANGO regions in 1A33_HUMAN
N-term gatekeepersTANGO regionC-term gatekeepersStartEndScore
VMAPRTLLLLLLGALALTQTWAGS82170
RGEPRFIAVGYVDDTQF465277
FYPAEITLTWQRDGE23724113
QPTIPIVGIIAGLVLFGAVFAGAVVAAVRWRRK30833069
TANGO aggregation profile score plot


This graph plots the per-residue TANGO aggregation score of the protein 1A33_HUMAN. From left to right, all residue scores from the N-terminus to the C-terminus are plotted


Molecular visualization of TANGO aggregation-prone regions

Wild type 1A33_HUMAN

This molecular image shows the TANGO aggregation-prone regions as red colored segments. Click on the image to get a larger view and to download the original.


WALTZ amylogenic profile of 1A33_HUMAN

WALTZ regions in 1A33_HUMAN
N-term gatekeepersWALTZ regionC-term gatekeepersStartEndScore
TLRCWALSFYPAEITL2292346
WALTZ aggregation profile score plot


This graph plots the per-residue WALTZ amylogenic score of the protein 1A33_HUMAN. From left to right, all residue scores from the N-terminus to the C-terminus are plotted


Molecular visualization of WALTZ amylogenic regions

Wild type 1A33_HUMAN

This molecular image shows the WALTZ amylogenic regions as blue colored segments. Click on the image to get a larger view and to download the original.


LIMBO chaperone binding profile of 1A33_HUMAN

LIMBO regions in 1A33_HUMAN
N-term gatekeepersLIMBO regionC-term gatekeepersStartEndScore
MAPRTLLLLLLGALALTQT91788.9
AGSHTIQMMYGCDVGSDG11912626.4
IALNEDLRSWTAADMAAQ15316072.8
FYPAEITLTWQRDGEDQT237244100
GLPKPLTLRWEPSSQPTI29430197.7
LIMBO chaperone binding profile score plot


This graph plots the per-residue LIMBO chaperone binding score of the protein 1A33_HUMAN. From left to right, all residue scores from the N-terminus to the C-terminus are plotted


Molecular visualization of LIMBO chaperone binding regions

Wild type 1A33_HUMAN

This molecular image shows the LIMBO chaperone binding regions as pink colored segments. Click on the image to get a larger view and to download the original.


All mutations from 1A33_HUMAN

5 mutations listed

Variant UniProt ID Mutation Disease Mutation Type dTANGO dWALTZ dLIMBO ddG
VAR_004378 1A33_HUMAN M358V - Polymorphism 3 0 0 N.A.
VAR_056286 1A33_HUMAN N151K - Polymorphism 0 0 0 0.21
VAR_004376 1A33_HUMAN H195Y - Polymorphism 0 0 -328 -2.58
VAR_004375 1A33_HUMAN R41S - Polymorphism -1 0 0 -1.31
VAR_056287 1A33_HUMAN I166T - Polymorphism 0 -1 0 1.88
Comma Separated Values documentMicrosoft Excel document