| Compact overview of 1A69_HUMAN | ||
|---|---|---|
| UniProt Entry Name | 1A69_HUMAN | |
| Protein Name | HLA class I histocompatibility antigen, A-69 alpha chain | |
| Protein Function | Involved in the presentation of foreign antigens to the immune system. | |
| Length | 365 residues | Gene ontology overview of 1A69_HUMAN |
| Cellular component | Molecular function | Biological process | integral to membrane MHC class I protein complex | antigen processing and presentation of peptide antigen via MHC class I immune response interspecies interaction between organisms |
Phenotypic summary of 1A69_HUMAN
| Short stretch summary of 1A69_HUMAN | |||
|---|---|---|---|
| Predictor | Predicted regions overview | Stretches | Total score |
| Tango |  | 5 | 2931 |
| Waltz |  | 2 | 184 |
| Limbo |  | 5 | 3189 |
| Domain composition of 1A69_HUMAN | |||
| Database | Domain composition | Residue details | |
| PFAM |  | MHC_I (Residues 25-203), C1-set (Residues 212-295), MHC_I_C (Residues 336-364) | |
| SMART |  | IGc1 (Residues 222-293) | |
TANGO aggregation profile of 1A69_HUMAN
| TANGO regions in 1A69_HUMAN | |||||
|---|---|---|---|---|---|
| N-term gatekeepers | TANGO region | C-term gatekeepers | Start | End | Score |
| VMAPR | TLVLLLSGALALT | QTWAG | 8 | 20 | 51 |
| RGEPR | FIAVGYV | DDTQF | 46 | 52 | 77 |
| FYPAE | ITLTW | QRDGE | 237 | 241 | 13 |
| GTFQK | WAAVV | VPSGQ | 268 | 272 | 11 |
| QPTIP | IVGIIAGLVLFGAVITGAVVAAVMW | RRKSS | 308 | 332 | 63 |
| TANGO aggregation profile score plot | |
|---|---|
 | This graph plots the per-residue TANGO aggregation score of the protein 1A69_HUMAN. From left to right, all residue scores from the N-terminus to the C-terminus are plotted |
| Molecular visualization of TANGO aggregation-prone regions | |
|---|---|
 Wild type 1A69_HUMAN | |
This molecular image shows the TANGO aggregation-prone regions as red colored segments. Click on the image to get a larger view and to download the original. | |
WALTZ amylogenic profile of 1A69_HUMAN
| WALTZ regions in 1A69_HUMAN | |||||
|---|---|---|---|---|---|
| N-term gatekeepers | WALTZ region | C-term gatekeepers | Start | End | Score |
| FLRGY | HQYAYD | GKDYI | 138 | 143 | 22 |
| TLRCW | ALSFYP | AEITL | 229 | 234 | 6 |
| WALTZ aggregation profile score plot | |
|---|---|
 | This graph plots the per-residue WALTZ amylogenic score of the protein 1A69_HUMAN. From left to right, all residue scores from the N-terminus to the C-terminus are plotted |
| Molecular visualization of WALTZ amylogenic regions | |
|---|---|
 Wild type 1A69_HUMAN | |
This molecular image shows the WALTZ amylogenic regions as blue colored segments. Click on the image to get a larger view and to download the original. | |
LIMBO chaperone binding profile of 1A69_HUMAN
| LIMBO regions in 1A69_HUMAN | |||||
|---|---|---|---|---|---|
| N-term gatekeepers | LIMBO region | C-term gatekeepers | Start | End | Score |
| MAPRT | LVLLLSGA | LALTQ | 9 | 16 | 99.9 |
| VGSDW | RFLRGYHQ | YAYDG | 132 | 139 | 66.3 |
| TCVEW | LRRYLENG | KETLQ | 192 | 199 | 86.6 |
| FYPAE | ITLTWQRD | GEDQT | 237 | 244 | 45.8 |
| GLPKP | LTLRWEPS | SQPTI | 294 | 301 | 97.7 |
| LIMBO chaperone binding profile score plot | |
|---|---|
 | This graph plots the per-residue LIMBO chaperone binding score of the protein 1A69_HUMAN. From left to right, all residue scores from the N-terminus to the C-terminus are plotted |
| Molecular visualization of LIMBO chaperone binding regions | |
|---|---|
 Wild type 1A69_HUMAN | |
This molecular image shows the LIMBO chaperone binding regions as pink colored segments. Click on the image to get a larger view and to download the original. | |
All mutations from 1A69_HUMAN
3 mutations listed
| Variant | UniProt ID | Mutation | Disease | Mutation Type | dTANGO | dWALTZ | dLIMBO | ddG |
|---|---|---|---|---|---|---|---|---|
| VAR_056308 | 1A69_HUMAN | Q94H | - | Polymorphism | 0 | 0 | 0 | -0.55 |
| VAR_056307 | 1A69_HUMAN | R89G | - | Polymorphism | -1 | 0 | 0 | 1.11 |
| VAR_056309 | 1A69_HUMAN | D101N | - | Polymorphism | 0 | 0 | 0 | -2.04 |
