CASC5_HUMAN

Compact overview of CASC5_HUMAN
UniProt Entry Name	CASC5_HUMAN
Protein Name	Protein CASC5
Protein Function	Performs two crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Required for attachment of the kinetochores to the spindle microtubules. Directly links BUB1 and BUB1B to kinetochores. Part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore.
Length	2342 residues
Gene ontology overview of CASC5_HUMAN
Cellular component	Molecular function	Biological process
acrosomal vesicle condensed chromosome kinetochore cytosol nucleoplasm	protein binding	acrosome assembly attachment of spindle microtubules to kinetochore cell division CenH3-containing nucleosome assembly at centromere mitotic prometaphase spindle assembly checkpoint

Phenotypic summary of CASC5_HUMAN

Short stretch summary of CASC5_HUMAN
Predictor	Predicted regions overview	Stretches	Total score
Tango		16	4051
Waltz		29	5452
Limbo		37	18760
Domain composition of CASC5_HUMAN
Database	Domain composition	Residue details

TANGO aggregation profile of CASC5_HUMAN

TANGO regions in CASC5_HUMAN
N-term gatekeepers	TANGO region	C-term gatekeepers	Start	End	Score
ETGEN	LLLIQ	NKKLE	117	121	12
ATSHN	IVYCGGVL	DKQIT	698	705	8
LTKSH	TVVIGF	GPSEL	795	800	54
AGTSE	TILYTC	RQDDM	930	935	13
RPMDK	TVVFV	DNHVE	968	972	88
LKNDK	TIVFS	ENHKN	1101	1105	7
RPMDK	TVLFT	DNYSD	1180	1184	15
KGQLD	CVITL	HKDQD	1407	1411	14
LNSEE	WFAAAC	KKELK	1524	1529	12
GKTGE	FLAFQT	VHLPP	1597	1602	6
ITIRE	FFILLQVHILI	QKPRQ	1899	1909	72
WSDDQ	AVFTFVY	DTIQL	2145	2151	80
LLVHK	LIFQYV	EEKES	2201	2206	54
KMLEE	FSLVV	HHCRL	2229	2233	9
LFSSS	AAFAKFEITLFLSAY	YPSVP	2273	2287	51
TSQDD	IATIL	SKVPL	2309	2313	18

TANGO aggregation profile score plot
	This graph plots the per-residue TANGO aggregation score of the protein CASC5_HUMAN. From left to right, all residue scores from the N-terminus to the C-terminus are plotted

WALTZ amylogenic profile of CASC5_HUMAN

WALTZ regions in CASC5_HUMAN
N-term gatekeepers	WALTZ region	C-term gatekeepers	Start	End	Score
TETGE	NLLLIQ	NKKLE	116	121	56
QMQQK	EFSIIE	HTRER	151	156	18
KHAND	QTVIFS	DENQM	167	172	59
DSRMK	KEVNFS	VDQNT	223	228	34
RESKG	NDITIY	GNDFM	335	340	12
YGNDF	MDLTFN	HTLQI	345	350	11
SIQGC	KTVFYS	SCNDA	452	457	43
KNLLK	HDSNYA	KMYCN	481	486	38
DITKS	HTVAID	NQIFK	516	521	6
NTVSW	EQSLFS	TTKPL	718	723	10
EMTES	HTVFID	YQEKE	984	989	24
IRPMD	KTVLFT	DNYSD	1179	1184	16
EVTDS	HTVFID	CQATE	1196	1201	24
LHTEQ	KQQLFA	ATNRT	1256	1261	64
YCPVQ	NDLAYA	NDFAS	1363	1368	35
YANDF	ASEYYL	ESEGQ	1372	1377	18
PLPKK	GQSSIN	KEEVI	1482	1487	7
KAGNK	SLNIIE	NSSAP	1500	1505	9
PKILN	SEEWFA	AACKK	1521	1526	10
ATEIH	NINIIS	SNAKD	1633	1638	88
TEEKA	LIETYQ	KEISP	1764	1769	11
YVYRP	KIQIYR	EDCEA	1942	1947	11
DKELK	AFGIYL	NKIKS	1992	1997	91
WSDDQ	AVFTFV	YDTIQ	2145	2150	34
FVYDT	IQLTIT	FEESV	2154	2159	10
RYRKI	VDVNFQ	SLLDE	2178	2183	80
LLVHK	LIFQYV	EEKES	2201	2206	17
FEITL	FLSAYY	PSVPL	2283	2288	6
LSKVP	LENNYL	KNVVK	2318	2323	25

WALTZ aggregation profile score plot
	This graph plots the per-residue WALTZ amylogenic score of the protein CASC5_HUMAN. From left to right, all residue scores from the N-terminus to the C-terminus are plotted

LIMBO chaperone binding profile of CASC5_HUMAN

LIMBO regions in CASC5_HUMAN
N-term gatekeepers	LIMBO region	C-term gatekeepers	Start	End	Score
RRHSS	ILKPPRSP	LQDLR	26	33	100
MVPSQ	LQLLPPGF	KRFSC	93	100	19.9
TETGE	NLLLIQNKK	LEDNY	116	124	71.2
IFSDE	NQMDLTSS	HTVMI	175	182	16.3
VMITK	GLLDNPIS	EKSTK	190	197	55.9
FNDFI	KRLKTGKC	SAFPD	246	253	7.2
PDKEN	FEIPIYSK	EPNSA	265	272	82.3
ENNSN	ITRLFREK	DDGMN	296	303	9.7
TFNHT	LQILPATG	NFSEI	353	360	93.3
NSADK	IHITRSHI	MGAET	409	416	47.7
MREEK	NLLKHDSN	YAKMY	477	484	89.8
APTPE	KEMMLQNLMTTSED	GKMNV	542	555	57
KDKDW	VLKILPYL	DKDSP	671	678	100
TKSHT	VVIGFGPS	ELQEL	796	803	68.3
PKEKQ	NVKIWGRK	SVGGP	870	877	99.9
TESHT	VFIDYQEK	ERTDR	986	993	16.8
TDRPN	FELSQRKS	LGTPT	1001	1008	81.6
KLKND	KTIVFSEN	HKNDM	1100	1107	30.2
LAGAS	KTILYSCG	QDDME	1141	1148	23
LLPNE	IAIRPMDK	TVLFT	1172	1179	72.1
LAVGN	KIVLHTEQ	KQQLF	1248	1255	6
TNRTT	NEIIKFHS	AAMDE	1268	1275	77.2
AAMDE	KVIGKVVD	QACTL	1281	1288	16.3
DFASE	YYLESEGQ	PLSAP	1375	1382	98.6
YVDDI	YVIPQPHF	STDQP	1464	1471	99.7
AAACK	KELKENIQTTNYNT	ALDFH	1531	1544	41.7
LAFQT	VHLPPLPE	QLLEL	1603	1610	68.7
LPEQL	LELGNKAH	NDMHI	1613	1620	31.1
RCSLG	IFLPRLPN	KRNCS	1678	1685	100
EEKAL	IETYQKEISPYEN	KMGKT	1765	1777	35
KKIRK	NEIKFSDT	TQDRE	1806	1813	21
KSANS	VLIKNLSR	TPSSC	1835	1842	69.3
ITIRE	FFILLQVH	ILIQK	1899	1906	96
SNQDK	LLVDINKN	LWEKM	1970	1977	22.6
LKAFG	IYLNKIKS	CFTKM	1995	2002	65
SLSEW	DVVEWSDD	QAVFT	2136	2143	100
GEEIE	YLKRWGPN	YNLMN	2245	2252	100

LIMBO chaperone binding profile score plot
	This graph plots the per-residue LIMBO chaperone binding score of the protein CASC5_HUMAN. From left to right, all residue scores from the N-terminus to the C-terminus are plotted

All mutations from CASC5_HUMAN

11 mutations listed

Variant	UniProt ID	Mutation	Disease	Mutation Type	dTANGO	dWALTZ	dLIMBO	ddG
VAR_026428	CASC5_HUMAN	R43T	-	Polymorphism	-1	0	0	N.A.
VAR_026429	CASC5_HUMAN	T70A	-	Polymorphism	0	0	0	N.A.
VAR_026430	CASC5_HUMAN	T113A	-	Polymorphism	0	-1	0	N.A.
VAR_026432	CASC5_HUMAN	R936G	-	Polymorphism	-67	1	0	N.A.
VAR_026431	CASC5_HUMAN	A486S	-	Polymorphism	0	-79	0	N.A.
VAR_026433	CASC5_HUMAN	K1285E	-	Polymorphism	-4	0	-1	N.A.
VAR_026434	CASC5_HUMAN	T1473A	-	Polymorphism	0	0	0	N.A.
VAR_061568	CASC5_HUMAN	M177V	-	Polymorphism	0	0	-47	N.A.
VAR_054342	CASC5_HUMAN	M598T	-	Polymorphism	0	0	44	N.A.
VAR_061569	CASC5_HUMAN	L1190V	-	Polymorphism	0	0	0	N.A.
VAR_061570	CASC5_HUMAN	C2338Y	-	Polymorphism	0	4	0	N.A.

Comma Separated Values document

Microsoft Excel document