PTPRT_HUMAN | SNPeffect 4.0

Compact overview of PTPRT_HUMAN
UniProt Entry Name	PTPRT_HUMAN
Protein Name	Receptor-type tyrosine-protein phosphatase T
Protein Function	May be involved in both signal transduction and cellular adhesion in the CNS.
Length	1441 residues
Gene ontology overview of PTPRT_HUMAN
Cellular component	Molecular function	Biological process
cell surface integral to membrane plasma membrane	alpha-catenin binding beta-catenin binding cadherin binding delta-catenin binding gamma-catenin binding protein tyrosine phosphatase activity receptor activity	homophilic cell adhesion protein dephosphorylation transmembrane receptor protein tyrosine kinase signaling pathway

Phenotypic summary of PTPRT_HUMAN

Short stretch summary of PTPRT_HUMAN
Predictor	Predicted regions overview	Stretches	Total score
Tango		22	6432
Waltz		20	4828
Limbo		19	12458
Domain composition of PTPRT_HUMAN
Database	Domain composition	Residue details
SMART		MAM (Residues 27-191), IG (Residues 198-286), FN3 (Residues 288-371), FN3 (Residues 384-473), FN3 (Residues 485-575), PTPc (Residues 910-1167), PTPc (Residues 1196-1461)
PFAM		MAM (Residues 32-191), fn3 (Residues 290-374), fn3 (Residues 498-578), Y_phosphatase (Residues 934-1164), Y_phosphatase (Residues 1224-1458)

TANGO aggregation profile of PTPRT_HUMAN

TANGO regions in PTPRT_HUMAN
N-term gatekeepers	TANGO region	C-term gatekeepers	Start	End	Score
MAS	LAALALSLLL	RLQLP	4	13	39
TFWPH	FYQVIF	ESVSL	160	165	46
NGRDT	ALMVT	RVVNH	236	240	9
IAPPE	LLAVGATYLWI	KPNAN	297	307	95
LQWEP	FGYAV	TRCHS	410	414	10
CHSYN	LTVQYQYVF	NQQQY	422	430	11
PFEEK	IYIQW	KPPNE	502	506	8
NETNG	VITLY	EINYK	515	519	27
NETHH	LFVGL	YPGTT	552	556	17
LNETD	TTITVML	KPAQS	605	611	44
SRGAP	VSVYQLVV	KEERL	621	628	75
SPLKS	YSIYF	QALSK	701	705	8
TVKMA	GVIAGLLMFIIILLGVMLTI	KRRRN	749	768	80
WQENS	ASIVMVTNLV	EVGRV	981	990	43
IETEP	LAEYVIRTFTV	QKKGY	1021	1031	14
CYATG	LLGFV	RQVKF	1062	1066	11
GAGRT	GCFIAI	DTMLD	1092	1097	10
DRCLP	FLISV	DGESS	1220	1224	20
SHKQP	AAFVVT	QHPLP	1244	1249	57
PLPNT	VADFWRLVF	DYNCS	1257	1265	11
QNIID	VFHIV	KTLRN	1406	1410	23
TLEQY	KFVYEV	ALEYL	1428	1433	6

TANGO aggregation profile score plot
	This graph plots the per-residue TANGO aggregation score of the protein PTPRT_HUMAN. From left to right, all residue scores from the N-terminus to the C-terminus are plotted

Molecular visualization of TANGO aggregation-prone regions
Wild type PTPRT_HUMAN
This molecular image shows the TANGO aggregation-prone regions as red colored segments. Click on the image to get a larger view and to download the original.

WALTZ amylogenic profile of PTPRT_HUMAN

WALTZ regions in PTPRT_HUMAN
N-term gatekeepers	WALTZ region	C-term gatekeepers	Start	End	Score
NDTHC	IDFHYYF	SSRDR	103	109	43
RSSPG	ALNVYV	KVNGG	119	124	34
EGWVK	AELAIS	TFWPH	149	154	11
FWPHF	YQVIFE	SVSLK	161	166	94
SDGGS	GVSNYAELIV	KEPPT	276	285	44
PVHGP	QNVEIV	DIRAR	391	396	7
NLTVQ	YQYVFN	QQQYE	426	431	26
TNGVI	TLYEIN	YKAVG	517	522	11
LSPLK	SYSIYF	QALSK	700	705	79
RRNAY	SYSYYL	KLAKK	776	781	64
RNKNR	YGNIIS	YDHSR	918	923	7
HSDYI	NANYID	GYHRP	944	949	42
CEFRS	LYYNIS	RLDPQ	1159	1164	64
IKDEF	QTLNIV	TPRVR	1180	1185	15
SVDGE	SSNYIN	AALMD	1228	1233	6
GCYGP	IQVEFV	SADID	1299	1304	69
YRIVQ	HLQYIG	WPAYR	1334	1339	39
GGRSG	TFCAIC	SVCEM	1387	1392	10
VCEMI	QQQNIID	VFHIV	1399	1405	57
KFVYE	VALEYL	SSF	1433	1438	6

WALTZ aggregation profile score plot
	This graph plots the per-residue WALTZ amylogenic score of the protein PTPRT_HUMAN. From left to right, all residue scores from the N-terminus to the C-terminus are plotted

Molecular visualization of WALTZ amylogenic regions
Wild type PTPRT_HUMAN
This molecular image shows the WALTZ amylogenic regions as blue colored segments. Click on the image to get a larger view and to download the original.

LIMBO chaperone binding profile of PTPRT_HUMAN

LIMBO regions in PTPRT_HUMAN
N-term gatekeepers	LIMBO region	C-term gatekeepers	Start	End	Score
ALALS	LLLRLQLP	PLPGA	11	18	99.9
GQKAH	LLLPTLKE	NDTHC	90	97	99.8
RKAPH	FLRLQNVE	VNVGQ	195	202	97.8
VGATY	LWIKPNAN	SIIGD	305	312	69.6
IRARQ	LTLQWEPF	GYAVT	403	410	100
PFEEK	IYIQWKPP	NETNG	502	509	100
NETHH	LFVGLYPG	TTYSF	552	559	76.5
ETDTT	ITVMLKPA	QSRGA	607	614	14.4
APVSV	YQLVVKEE	RLQKS	624	631	85.5
AYSYS	YYLKLAKK	QKETQ	779	786	95.2
LSQPT	LTIQTHPY	RTCDP	843	850	94.6
TVKDF	WRMIWQEN	SASIV	972	979	56.2
EPLAE	YVIRTFTV	QKKGY	1024	1031	13
HEIRE	LRLFHFTSWPDH	GVPCY	1042	1053	57.3
CVREL	RAQRV	NLVQT	1120	1124	94.1
EDCSI	GLLPRNHD	KNRSM	1197	1204	89.9
VADFW	RLVFDYNC	SSVVM	1262	1269	98.1
IVQHL	QYIGWPAY	RDTPP	1336	1343	98.7
NIIDV	FHIVKTLRNNKS	NMVET	1407	1418	64.3

LIMBO chaperone binding profile score plot
	This graph plots the per-residue LIMBO chaperone binding score of the protein PTPRT_HUMAN. From left to right, all residue scores from the N-terminus to the C-terminus are plotted

Molecular visualization of LIMBO chaperone binding regions
Wild type PTPRT_HUMAN
This molecular image shows the LIMBO chaperone binding regions as pink colored segments. Click on the image to get a larger view and to download the original.

All mutations from PTPRT_HUMAN

28 mutations listed

Variant	UniProt ID	Mutation	Disease	Mutation Type	dTANGO	dWALTZ	dLIMBO	ddG
VAR_020749	PTPRT_HUMAN	F248S	A colorectal cancer	Unclassified	-11	0	0	N.A.
VAR_020747	PTPRT_HUMAN	A209T	Some colorectal cancers	Unclassified	0	0	0	N.A.
VAR_020751	PTPRT_HUMAN	I395V	A colorectal cancer	Unclassified	1	-41	0	N.A.
VAR_020748	PTPRT_HUMAN	K218T	A gastric cancer	Unclassified	-2	0	0	N.A.
VAR_020752	PTPRT_HUMAN	Y412F	A colorectal cancer	Unclassified	95	0	0	N.A.
VAR_020753	PTPRT_HUMAN	R453C	A gastric cancer	Unclassified	-2	0	0	N.A.
VAR_020746	PTPRT_HUMAN	F74S	A colorectal cancer	Unclassified	-10	0	0	N.A.
VAR_020755	PTPRT_HUMAN	T605M	A colorectal cancer	Unclassified	49	0	0	N.A.
VAR_020758	PTPRT_HUMAN	A707V	A colorectal cancer	Unclassified	187	-45	0	N.A.
VAR_020757	PTPRT_HUMAN	A707T	A colorectal cancer	Unclassified	-7	1	-3	N.A.
VAR_020756	PTPRT_HUMAN	V648G	A colorectal cancer	Unclassified	0	0	0	N.A.
VAR_020750	PTPRT_HUMAN	Y280H	A colorectal cancer	Unclassified	0	-203	0	N.A.
VAR_020768	PTPRT_HUMAN	R1324L	A lung cancer	Unclassified	-2	0	0	N.A.
VAR_020766	PTPRT_HUMAN	M1237L	A colorectal cancer	Unclassified	5	0	0	N.A.
VAR_020769	PTPRT_HUMAN	Y1329F	A colorectal cancer	Unclassified	0	0	0	N.A.
VAR_020767	PTPRT_HUMAN	V1247M	A colorectal cancer	Unclassified	-263	-1	0	N.A.
VAR_020754	PTPRT_HUMAN	N510K	A colorectal cancer	Unclassified	3	0	0	N.A.
VAR_020765	PTPRT_HUMAN	R1190W	A colorectal cancer	Unclassified	-2	0	0	N.A.
VAR_020760	PTPRT_HUMAN	R771I	A lung cancer	Unclassified	-1	0	0	N.A.
VAR_020761	PTPRT_HUMAN	D905G	A colorectal cancer	Unclassified	0	0	0	0.01
VAR_020759	PTPRT_HUMAN	L708P	A colorectal cancer	Unclassified	-21	3	-1	N.A.
VAR_020763	PTPRT_HUMAN	A1096P	A colorectal cancer	Unclassified	-61	-8	9	6.68
VAR_028795	PTPRT_HUMAN	A29P	-	Polymorphism	0	0	0	N.A.
VAR_020762	PTPRT_HUMAN	Q965K	A colorectal cancer	Unclassified	2	0	0	-0.46
VAR_020764	PTPRT_HUMAN	N1106I	A colorectal cancer	Unclassified	0	0	0	0.07