RRP8_HUMAN

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Compact overview of RRP8_HUMAN
UniProt Entry NameRRP8_HUMAN
Protein NameRibosomal RNA-processing protein 8
Protein FunctionEssential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys- 9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.
Length456 residues
Gene ontology overview of RRP8_HUMAN
Cellular componentMolecular functionBiological process
chromatin silencing complex
nucleolus
rDNA heterochromatin
methylated histone residue binding
S-adenosylmethionine-dependent methyltransferase activity
chromatin modification
chromatin silencing at rDNA
rRNA processing
transcription

Phenotypic summary of RRP8_HUMAN

Short stretch summary of RRP8_HUMAN
PredictorPredicted regions overviewStretchesTotal score
Tango 3880
Waltz 31115
Limbo 73797
Domain composition of RRP8_HUMAN
DatabaseDomain compositionResidue details
PFAMMethyltransf_8 (Residues 237-456)

TANGO aggregation profile of RRP8_HUMAN

TANGO regions in RRP8_HUMAN
N-term gatekeepersTANGO regionC-term gatekeepersStartEndScore
QEDPEAFLLYHRGFQ27628064
LRQRPASLVVADFGCG30831319
DESVDVAVFCLSLMGTNIR35936746
TANGO aggregation profile score plot


This graph plots the per-residue TANGO aggregation score of the protein RRP8_HUMAN. From left to right, all residue scores from the N-terminus to the C-terminus are plotted


Molecular visualization of TANGO aggregation-prone regions

Wild type RRP8_HUMAN

This molecular image shows the TANGO aggregation-prone regions as red colored segments. Click on the image to get a larger view and to download the original.


WALTZ amylogenic profile of RRP8_HUMAN

WALTZ regions in RRP8_HUMAN
N-term gatekeepersWALTZ regionC-term gatekeepersStartEndScore
RFRYLNEQLYSGPSSA25526058
QEDPEAFLLYHRGFQS27628126
DLTNSHFFLFDFQKTG42342897
WALTZ aggregation profile score plot


This graph plots the per-residue WALTZ amylogenic score of the protein RRP8_HUMAN. From left to right, all residue scores from the N-terminus to the C-terminus are plotted


Molecular visualization of WALTZ amylogenic regions

Wild type RRP8_HUMAN

This molecular image shows the WALTZ amylogenic regions as blue colored segments. Click on the image to get a larger view and to download the original.


LIMBO chaperone binding profile of RRP8_HUMAN

LIMBO regions in RRP8_HUMAN
N-term gatekeepersLIMBO regionC-term gatekeepersStartEndScore
KGSKRRQLLATLRALEAA3845100
DSEEEVERKKKCHKQALV11011720.7
SDSAEDEKRKRKCQKHAP12913654
PPHTLSRKQWRNRQKNKRRCKNKFQ18419852.7
EDPEAFLLYHRGFQSQVK277284100
LEEANRVLKPGGLLKVAE38038779.2
SRFEDVRTFLRAVTKLGF40040719.5
LIMBO chaperone binding profile score plot


This graph plots the per-residue LIMBO chaperone binding score of the protein RRP8_HUMAN. From left to right, all residue scores from the N-terminus to the C-terminus are plotted


Molecular visualization of LIMBO chaperone binding regions

Wild type RRP8_HUMAN

This molecular image shows the LIMBO chaperone binding regions as pink colored segments. Click on the image to get a larger view and to download the original.


All mutations from RRP8_HUMAN

2 mutations listed

Variant UniProt ID Mutation Disease Mutation Type dTANGO dWALTZ dLIMBO ddG
VAR_051034 RRP8_HUMAN A145P - Polymorphism 0 0 0 N.A.
VAR_051035 RRP8_HUMAN P329S - Polymorphism 1 0 0 2.38
Comma Separated Values documentMicrosoft Excel document